A 7-month-old Miniature Poodle acquired from a pet store developed cough and subsequently respiratory distress compatible with Bordetella bronchiseptica infection.Partial but incomplete resolution of clinical signs and thoracic radiographic/computed tomographic imaging lesions were noted with use of susceptibility-guided antimicrobials.Additionally, a concern for an infectious nidus led to left cranial lung lobectomy at TOUK-TOUK SMOOTHIE CUBES 9 months of age.Histopathology predominantly revealed polypoid and constrictive bronchiolitis obliterans (i.e.
, small airway disease).Intermittent antimicrobial administration over the next 5 years failed to blunt progressive clinical signs.At 8 years, necropsy confirmed severe airway-centered interstitial fibrosis.This pattern of fibrosis was strongly suggestive of underlying small airway disease as the trigger.In retrospect, post-infectious bronchiolitis obliterans (PIBO), a syndrome in young children caused by pulmonary infections but not yet recognized in pet dogs, likely initiated a pathway of fibrosis in this dog.
In dogs with risk factors for community-acquired pathogens such as Bordetella bronchiseptica, PIBO is a differential diagnosis with development of severe, persistent respiratory signs incompletely responsive to appropriate antimicrobials.Untreated PIBO may lead Casual Seating Set to airway-centered interstitial fibrosis.Future study is required to determine if targeted therapy of PIBO could alter the course of end-stage pulmonary fibrosis.